Nortje will now miss a second consecutive World Cup due to a persistent back problem.

Sisanda Magala, 32, has also been forced to withdraw from the squad due to an injury.

In this month’s 3-2 win over Australia, both men played one-day international cricket at home.

A fractured thumb caused Nortje to miss the 2019 World Cup, and Cricket SA stated: “The risk associated with his inclusion in the squad outweighed his obvious value to the squad.”

In the third ODI of the five-match series against Australia, Magala was limited to four overs due to a knee injury.

To replace the injured pair in the 15-man squad, South Africa’s white-ball coach Rob Walter has called up all-rounder Andile Phehlukwayo and fast bowler Lizaad Williams.

Nortje and Magala’s loss was “hugely disappointing,” but Walter added: “This gives Andile and Lizaad a chance to shine on the global stage.”

On Saturday, 7 October, South Africa will open their World Cup campaign against Sri Lanka in Delhi.

South Africa’s World Cup squad: Temba Bavuma (c), Gerald Coetzee, Quinton de Kock, Reeza Hendricks, Marco Jansen, Heinrich Klaasen, Keshav Maharaj, Aiden Markram, David Miller, Lungi Ngidi, Andile Phehlukwayo, Kagiso Rabada, Tabraiz Shamsi, Rassie van der Dussen, Lizaad Williams.